PhD Confirmation Review, Charlotte Nejad (23 March) "Investigation of the regulation of miRNA turnover in mammalian cells"

All staff and students are invited to Charlotte Nejad's PhD Confirmation of Candidature Review on 23 March, 9.30 - 11.30am, Board Room 1a and b at the Hudson Institute of Medical Research, Level 3.

Synopsis:  Previous reports indicate that the intracellular levels of selected miRNAs can be rapidly down regulated by innate immunity. In this project we investigated the global stability of miRNAs in activated mouse macrophages. We made several novel observations demonstrating the degradation of several abundant miRNAs by IFN-β, likely impacting the innate immune program in these cells.

- Supervisors: Dr. Michael Gantier (Main supervisor), Dr. Jonathan Ferrand (Co-supervisor)

- SAC: Prof. Michael Hickey

- Two independent assessors: Dr. Ina Rudolff, Dr. Ashley Mansell