MHTP Infectious and Inflammatory Diseases Theme Special Seminar: TODAY 9 August

12:00 - 1:00pm, Seminar Room 1, Level 2, TRF Building

Prof Branch Moody

Professor of Medicine

Brigham and Women’s Hospital

Harvard Medical School

Harvard Club of Australia Fellow

CD1-Reactive T cells Mediate Human Response to Tuberculosis Infection

After more than two decades of focus on T cell recognition of MHC-peptide, immunologists were surprised to learn that T cell receptors recognize lipid antigens bound to CD1 proteins.  Emphasizing recently published and unpublished data, the talk explains that many lipids are displayed by cellular CD1 proteins and describes ex vivo T cell responses detected by CD1 tetramers in tuberculosis patients.  These studies provide several further surprises and a broader view of T cell function that includes response to cellular lipids.  

Originally from Irving, Texas, Dr. Moody is a graduate of the Johns Hopkins University School of Medicine and serves as physician and immunologist at Harvard Medical School.  His laboratory focuses on basic and applied research on how human T cells and macrophages respond to infection in human tuberculosis disease. This work is supported by the NIH Tuberculosis Research Unit Network, the Pew Foundation, the Burroughs Welcome Foundation and the Bill and Melinda Gates Foundation.

A light lunch is served prior to the seminar at 11:45am in the seminar room foyer, level 2, TRF Building.

Further information available from CID Weekly Seminar Series website [http://www.med.monash.edu.au/scs/medicine/cid/seminar-series.html