Position Description
Cartherics is seeking Post-Doctoral Fellows to help
implement its very active research program in Chimeric Antigen Receptor (CAR)-T
based immunotherapies. The successful applicants will have a strong background
in human T cell biology with experience in isolation, cell culture and
phenotypic and functional characterisation. They will have a desire to succeed
in a competitive environment and relish the challenge of helping to implement
new technologies and equipment as necessary; the rewards will be
substantial. They will report directly
to the Chief Scientific Officer of Cartherics but also liaise regularly with
the other research scientists and relevant Laboratory personnel.
The project has multiple programs incorporating in vitro
activation and numerical expansion of TCR-cancer specific T cells; gene
transfection with viral constructs; induction of T cells from pluripotential
stem cells. Accordingly the successful applicant will have extensive experience
in immunology-based research techniques with relevance to one or more of the
key research platforms:
1. The isolation and functional expansion of human blood T cells
with a TCR specific for a nominal cancer antigen; this will require extensive
knowledge of tetramer based flow cytometry, cell sorter, cytokine arrays, ultra-sterile
tissue culture ultimately in GMP/GLP conditions
2. The transfection of human T cells or iPSC with viral
(retroviral or lenti) constructs (these will contain Chimeric Antigen Receptor
specification)
3. The induction of T cells from CAR-T/ TCR specific stem or
progenitor cells in vitro using mimics of thymus –based T cell genesis;
functional analysis of safety and specificity. This involves tissue culture,
animal husbandry and handling, flow cytometry, immunohistochemistry, in vitro
and in vivo T cell cytotoxicity assays
In particular they will:
(i)
Have demonstrated
scientific knowledge and experience with a proven track record for performing
highest quality research including publications in leading journals;
(ii)
Have advanced
analytical skills with proven experience in human lymphocyte biology
(iii)
Ensure smooth running of the laboratory environment;
(iv)
Have well developed organizational skills required for
data management and documentation of standard operating procedures;
the ability to set priorities, manage time, work to meet deadlines and work
effectively under pressure.
(v)
Have excellent problem-solving
abilities including appraisal and improvement of laboratory technologies and practices
(vi)
Understand the
requirements and confidentialities for corporate funded research;
Education/Qualifications
The
appointees will have a PhD and 3+ years Postdoctoral experience in T cell
biology from a recognized university or research institute.
Company Description
Cartherics Pty Ltd is an exciting
new Melbourne-based start-up biotechnology company, developing the next
generation immune therapeutic approach to treat cancer. The Company’s objective
is to combine the best weapons of the immune system that have evolved so
effectively to combat infections, to now target and destroy cancer. The essence is to identify and expand T cells
with their own cancer recognizing T Cell Receptors (TCRs), then use
sophisticated molecular engineering to empower these cells with additional
cancer-specific recognition and activation molecules (“Chimeric Antigen
Receptors”: CAR-T) that can not only track down the cells but also deliver a
supercharged “killer blow”. Furthermore we will use stem cell technology to
exponentially expand these “cancer smart” killer cells, thereby enabling a
quantum increase in the destructive power of a patient’s immune system. The ultimate
goal, is to give Cartherics an international leadership position in immune cell
and stem cell therapies. Cartherics, in association with the Hudson Institute
for Medical Research, is expected to be located within the new facilities of
the Monash Health Translation Precinct, Monash Medical Centre, Clayton Road,
Clayton (Melbourne), Victoria, Australia
Send
application with C.V including potential referees to:
Professor
Richard Boyd
Chief
Scientific Officer,
Cartherics,
Pty Ltd.
Email:
richard.boyd@monash.edu
Telephone
inquiries +61 419 317 533
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