
3:30pm-4:00pm, Tuesday, 12th December
MIMR building Level 3 - Board Room
Synopsis: Gastric cancer (GC) is the third most lethal cancer worldwide, and one of the classic examples of chronic inflammation-related carcinoma. The interaction between host innate immune system regulators (e.g. pattern recognition receptors, PRRs) and pathogens (e.g. Helicobacter pylori) contributes to gastric tumorigenesis. We focus on the mechanistic role of three such PRRs, TLR2, TLR9 and AIM2, in GC, and their relationships with hyper-activation of the signal transducer and activator of transcription (STAT) 3, to identify new GC molecular targets to serve as personalised biomarkers for early detection and/or treatment strategies.
Supervisors: Professor Brendan Jenkins, Dr Daniel Gerald Croagh
PhD Training Program: Biomedical Sciences Doctoral Program
Panel members and independent advisors:
Panel Chair: Dr Anthony Sadler
Independent Assessor: Dr James Harris
Independent Assessor: Dr Michael Gantier
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