Scientists from the School of Clinical Sciences at Monash Health (SCS), Monash University have discovered that two types of immune cells inside blood vessels work together to cause inflammatory kidney disease, paving the way for future targeted treatments. Using highly advanced microscopy techniques, the research team visualised monocytes and neutrophils in real time and saw the cells frequently interacting with each other in healthy glomeruli.
Lead researcher Dr Michaela Finsterbusch from the Centre for Inflammatory Diseases said that during inflammation, the duration of the interactions was prolonged and was associated with a higher degree of disease-causing neutrophil activation.
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