Presented by Ms Andrea Godfrey, Postgraduate student, Centre for Inflammatory Diseases
Seminar Room 1, Translation Research
Facility
Myeloperoxidase
anti-neutrophil cytoplasmic antibody associated glomerulonephritis (MPO-ANCA
GN) is the most common cause of crescentic GN resulting from the development of
autoimmunity to MPO. Despite current therapies, the disease has a 30%, three
year morbidity or dialysis outcome with considerable toxicities. Hence
development of therapeutic strategies with a high efficacy are important. Here,
the novel therapeutic strategies described are aimed to; 1) re-establish
antigen specific tolerance by re-presenting the nephritogenic MPO peptide
conjugated chemically to apoptotic splenocytes and 2) enhance immunoregulation
by administering human amniotic epithelial stem cells. Both these strategies
have the capacity to improve kidney injury in experimental autoimmune MPO-ANCA
GN.
Lunch will be served at 11.45am in the
Seminar Room Foyer, level 2, TRF Building
(no food and drink in the seminar room)
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