Low vitamin D levels linked to lupus

Dr Kristy Yap

Monash-led research has shown for the first time that low vitamin D levels are associated with higher disease activity in Australian systematic lupus erythematosus (SLE) patients.

Published earlier this month in Lupus Science & Medicine, lead researcher Dr Kristy Yap, MBBS from the Centre for Inflammatory Diseases in the School of Clinical Sciences reported her findings in the first study to examine SLE disease in the Southern Hemisphere.

SLE, also known as lupus, is a severe, incurable and debilitating multisystem autoimmune disease.  It is the most common autoimmune disease, affecting at least 5 million people worldwide, and is predominantly diagnosed in young women.

The longitudinal study examined the disease activity and vitamin D levels of lupus patients who attended the Monash Medical Centre Lupus Clinic between 2007 and 2013.

“We found a high prevalence of vitamin D deficiency in our cohort,” said lead author Dr Kristy Yap.

“Significantly, over a quarter of our patients recorded low vitamin D levels, keeping with reports from other parts of the world, including Asia and Europe.”

Demonstrating an inverse association between vitamin D levels and lupus disease activity, the research shows that increasing vitamin D levels correlates with lower disease activity in lupus patients.

“Future studies should include randomised trials which focus on the clinical effect of vitamin D supplementation in lupus,” said Head of the Monash Lupus Clinic and chief investigator in the Lupus and Arthritis Research Group, Dr Alberta Hoi.