Monday, 29 May 2017

Google map data to locate best hospitals for patients with stroke

Associate Professor Henry Ma
A world-first study at Monash University has used Google map data to locate the hospitals to which patients with stroke should be transported for urgent and highly specialised treatment.

While stroke is a leading cause of death and disability worldwide, recent major advances in acute stroke management, such as endovascular clot retrieval (ECR), are bringing optimism to patients, their families and stroke clinicians.  ECR is a specialised procedure that is adopted to remove the clot blocking the affected artery in order to limit damage to the brain. A time-critical treatment, it requires highly skilled stroke teams, and is only available at a limited number of tertiary hospitals.

Published in the prestigious journal Stroke, the study was led by Monash University’s Professor Thanh Phan, who said the best outcomes for patients with stroke are achieved by rapid transport to hub hospitals designated to provide expert ECR treatment.

“Our team used Google map live data to decide the best distribution of patient transfers in Victoria,” said Professor Phan, who is a neurologist at Monash Health.

“In order to achieve the best outcomes for patients, we must objectively determine the areas a hub hospital can service so that ambulance personnel can make correct and quick decisions when transporting a person who has suffered a stroke. Our findings show that the combination of Monash Medical Centre and Royal Melbourne Hospital provides the best coverage for patients in Melbourne with regards to optimal transport time to hospital.”

“For the first time, we’ve developed new computational methods to access Google map data to reliably and objectively generate service boundaries for ECR hubs, defined by optimal traveling time to the hub,” said Professor Phan.

Senior co-author Velandai Srikanth, Professor of Medicine at Peninsula Health and the Peninsula Clinical School, Monash University said the data-driven method can be interactively applied at various times of the day, depending on traffic conditions, and removes any personal bias.

“This study has opened up the exciting possibility of real-time decision-making in efficient and rapid health care delivery for patients with acute stroke.”

This research is novel because the current use of ambulance transport data only provides traveling time to a hospital, and cannot be used to provide data on hospital catchment boundaries.

“The Google Map Application Programming Interface (API) allowed us to simulate travel from one location to multiple hospitals, enabling us for the first time to reliably simulate several real-time scenarios and generate optimal hub catchments,” said co-author Associate Professor Richard Beare, Head of Imaging and Bioinformatics at Peninsula Clinical School, Monash University.  

The research team calculated transport times to four ECR capable Melbourne hospitals from simulated addresses at four different times of day—8.15am, 12.30pm. 5.15pm and 1am – and used the best case scenario traffic model to approximate emergency ambulance transit.

To validate their model with real patient travel time data, the team compared their Google map time estimates with actual ambulance travel times for patients with stroke and found a very close correlation.

Head of Stroke at Monash Health Associate Professor Henry Ma said these simulated models can be used to identify the ideal hub for patient transfer. 

"We can also model and display the impact of traffic conditions on travel time and the catchment areas to hospital by generating interactive maps,” said Associate Professor Ma, co-author on the study.

“These maps can guide ambulance personnel in real-time identification of routes to the nearest ECR hub.”

“This approach is potentially applicable in other metropolitan cities in Australia and overseas when designing ECR services, or indeed other acute time-dependent conditions such as acute coronary syndrome,” said Associate Professor Ma.

The interactive maps developed by the research team can be viewed at

Monash Medical Centre will come online as the second statewide ECR centre later—The Royal Melbourne Hospital is already operating in this capacity.

Monash medical student’s research highlights unusual presentations of meningococcal disease

Wesley Teoh
Improved diagnosis and increased awareness of meningococcal disease is the focus of latest research at Monash University.
School of Clinical Sciences at Monash Health final year medical student Wesley Teoh undertook an interesting case study that highlights some atypical presentations of meningococcal disease and the importance of accurate diagnosis.
Published in the Journal of Clinical and Experimental Ophthalmology, Wesley also presented his research at the 1st Australasian Diagnostic Error in Medicine Conference in Melbourne this month.
In his case study, Wesley examined a 19 year old, fit and healthy male who presented from home to the Cabrini Emergency Department with what appeared to be viral conjunctivitis. The patient’s right eye was painful, red and watery.
“The symptoms developed fairly acutely—approximately 6 hours before he presented to the ED,” said Wesley.

“Assuming it was viral conjunctivitis, the emergency physician discharged him on lubricating eye drops, however, due to the severity and acuity of his symptoms, the physician sent off a swab of his right eye for cultures.” 

Wesley said that this is where the case became interesting, as the patient’s swab came back positive for meningococcal disease.

An extremely rare condition that is usually only seen in either young children or the elderly (due to the weakening of the immune system), meningococcal conjunctivitis can potentially lead to blindness, septicaemia and even death.

Since 2014, Victoria has experienced an increase in meningococcal disease and currently there is an outbreak of the Meningococcal W (MenW) strain, which was coincidentally the same strain Wesley’s patient case study grew on culture.

“The patient was recalled back to the hospital, admitted and put on intravenous and topical antibiotics. He was discharged after two days, following normal investigation results and ophthalmology review,” Wesley said. 

Wesley explained there are some interesting points worth highlighting in this case study.
“Firstly, the most common presentation of MenW is still septicaemia, however, MenW is also notorious for presenting atypically.”

“There are cases of septic arthritis, epiglottitis and pneumonia; the question is can conjunctivitis also be one of its ‘new’ atypical presentations?” Wesley said.

“Secondly, meningococcal disease usually affects people who live in crowded conditions (for example, those living in a dorm or a share house. But our patient lives at home with his family and is a fit and healthy cyclist.”

According to Wesley, the take home messages from this study are:
·         Be aware of the increase in meningococcal disease (especially MenW) in Victoria.
·         Be aware of MenW's atypical presentations - septic arthritis, epiglottitis, pneumonia and now conjunctivitis.
·         If a presumably benign condition (like viral conjunctivitis) looks unusual, investigate.
·         Meningococcal conjunctivitis is not benign and can cause blindness or even death.
·         Meningococcal conjunctivitis needs to be treated with both topical and intravenous antibiotics.
·         With the rising incidience of meningoccocus, vaccination is key to prevention!

Wesley acknowledges and thanks the patient and his family for allowing him to study his ‘interesting case’, as well as the doctors at Cabrini Hospital, including Dr Katherine Walker, Dr Antony Bottrall, Dr Eugene Teh, Dr Richard Stawell and Jenny Couper.

Professor Lois Salamonsen elected as Australian Academy of Science Fellow

Women’s reproductive health expert Professor Lois Salamonsen has been elected to the Australian Academy of Science, for her outstanding contributions to science.
Prof Salamonsen is one of 21 of Australia’s best scientists to be elected to the Academy in 2017, in a rare and esteemed honour.
“I feel enormously honoured and humbled by this selection. It is certainly the pinnacle of my career, and I thank my generous mentors who put my name forward for this,” Prof Salamonsen said.
Prof Salamonsen joins experts in kidney research, nanotechnology, geophysics, mobile telecommunications, astronomy and embryology in this year’s list of inductees. The group was elected by their Academy peers, following a rigorous evaluation process.
Prof Salamonsen’s career spans more than 30 years, with her research focused on human endometrial biology.
She has published more than 260 peer-reviewed publications in the fields of endometrial remodelling, implantation and endometriosis, and has >12,000 citations.
“I work particularly on the endometrium, which is the lining of the uterus. The endometrium is a truly remarkable tissue – it completely rebuilds itself 350-400 times in a woman’s life,” Prof Salamonsen said.
Her discoveries include determining the mechanisms underpinning menstruation, and the embryo –maternal cross-talk critical for embryo implantation. Her findings have important implications for infertility, abnormal uterine bleeding, endometriosis and development of new non-hormonal contraceptives for women.
“What happens during the early reproductive processes can affect the health of that individual for the rest of their life. This is therefore a key to a healthy population,” she said.
Professor Salamonsen was first inspired to become a scientist as a child – an interest later encouraged by her mentors.
“I was excited by science from a very early age. When I was a child, I collected bugs and read books about the universe,” Prof Salamonsen said.
“When I first came to Melbourne, I worked in the laboratory of Professor Henry Burger, renowned endocrinologist. It was through him that I became inspired by the complexity of reproduction. From then on, that was what I wanted to do.
“I have been strongly mentored also by my PhD supervisor and now colleague, Professor Jock Findlay, who along with Henry Burger has strongly supported me throughout my career.”
Prof Salamonsen says she is inspired by the diversity of nature, and by her scientific colleagues.
“When we make a discovery, it opens up a whole wealth of other directions that we need to follow. My colleagues and students share my enthusiasm for science,” she said.
Academy of Science President, Professor Andrew Holmes, congratulated all of the new Fellows for making significant and lasting impacts in their scientific disciplines.
Professor Salamonsen was formally inducted into the Academy last Monday at the Shine Dome in Canberra.

Centre for Inflammatory Diseases' Day of Immunology success

Guest speaker Dr Malkin
The Monash University Centre for Inflammatory Diseases held a highly successful Day of Immunology event at the Monash Health Translation Precinct last week.  

More than 40 people attended a public lecture, met with researchers and toured the labs.  Visitors included students from Wellington High School, Monash University Immunology  patients and families members and interested members of the public.

During the Public Lecture Dr Claire Dendle gave an overview of how the immune system works while Monash HIV Director, Dr Ian Woolley, presented on various infectious diseases in context with the theme of this year’s Day of Immunology, Preventable Pandemics.  Invited guest speaker Dr Carolyn Malkin, spoke about poliomyelitis in Victoria and the response to epidemics in the pre-vaccine era.

The event was also an opportunity for scientists, clinician-scientists, clinicians and postgraduate students to discuss their research and future study options.

Event organiser and CID Strategic Development Officer Dr Andrea Johannessen said that during the laboratory siscovery tours, participants were able to identify cell types using histology and microscopy techniques, view the immune system in action, tour the new Translational Research Facility and see the latest in world class research infrastructure.

"We were also delighted to exhibit the ‘Snapshots of the immune system’and there was great interest in the images and artwork of the immune system in action," she said.

Feedback from attendees was extremely positive.

Dr Johannessen thanks all  staff and students who participated on the day and to the CID Day of Immunology 2017 Organising Committee; Dr Holly Hutton, Dr Andrea Johannessen, Ms Kim O’Sullivan, Mr Raymond Shim, Ms Louisa Yeung and Dr Michaela Finsterbusch.

Call for participants in the Translational Research Young Investigator poster competition

The 3rd annual Monash University Translational Research (TR) Symposium will be held 31 July 2017. The event is hosted by the three Monash clinical schools and will showcase the diverse research from these schools.

A Young Investigator poster competition will be held, with a winning prize of $500. The competition is open to graduate student and early career researchers, who are within 5 years of completing their PhD. Entries now invited.

If you would like to participate in the poster competition, please RSVP here. Please provide a title for your poster and a 250 word abstract before 3 July 2017.

More information:
The Translational Research Symposium will host a variety of medical researchers and medical alumni, presenting their translational research.

Date: Monday 31 July, 2017
Time: 8:30 for 9:00am start - 7:00pm close
To find out more about the symposium and our speaker program, please visit the website.
Please register your attendance, for catering purposes.

Translational Research Symposium Speaker Spotlight: Professor Kathryn North, 31 July

Monash University's 3rd annual Translational Research Symposium is being hosted by its three metropolitan clinical schools on 31 July 2017. The symposium will host a diverse group of medical researchers presenting their work into translational research.

The Keynote speaker for the event is Professor Kathryn North AM, Director of the Murdoch Children's Research Institute, Director of the Victorian Clinical Genetics Service and the David Danks Professor of Child Health Research at the University of Melbourne.

Prof North's presentation will be "Genomics and the Brave New World of Personalised Medicine: A Global and Local Perspective".

Genomics is already having a huge impact on our ability to diagnose and understand a range of disorders, and to target therapies to the individual. However, effective integration of this “disruptive technology” into everyday clinical practice will require a “whole-of-system” approach that builds on existing expertise. In Australia, we also need to overcome the “state/federal divide” in the funding of genetic testing to develop a cohesive national approach that is cost effective and provides equitable access.

The Australian Genomics Health Alliance (AGHA) is an NHMRC-funded national collaborative network committed to implementing genomic medicine within Australia and providing evidence to inform policy and practice. AGHA comprises over 50 partner organisations including the diagnostic pathology and clinical genetics services of all Australian States and Territories, along with the major research and academic institutions and peak professional bodies. By approaching clinical genomics at a national rather than state-based level, we increase our critical mass and offer a single point of contact for government and for national and international consortia.

Our approach – starting with the patient and developing a system that is focussed on improving patient care and outcomes – provides us with a unique opportunity to lead internationally in the integration of genomics into healthcare.

AGHA is also a leading member of the Global Alliance for Genomics and Health (GA4GH), an organisation of over 470 of the world’s leading biomedical research institutions, healthcare providers, information technology and life science companies, funders of research, and disease and patient advocacy organizations. The Global Alliance aims to accelerate the world-wide effort to responsibly aggregate, analyse and share large amounts of genomic and clinical information to advance the understanding, diagnosis, and treatment for cancer, inherited diseases, infectious diseases, and drug responses.

We look forward to welcoming Professor North for the Symposium!

More information:
Translational Research Symposium
  • Date: Monday 31 July, 2017
  • Time: 8:30 for 9:00am start - 7:00pm close
  • RSVP here

Find out more about the symposium and our speaker program.

If you are a graduate student or early career researcher, you may be interested in the Young Investigator poster competition. See here for more details and to RSVP.

CID Weekly Seminar Series: "Novel approaches for tackling the diabetic heart", 30 May

Tuesday 30 May, 12:00 - 1:00pm, Seminar Room 1, TRF Building

A/Prof Rebecca Ritchie
Head of Heart Failure Pharmacology, Baker Heart and Diabetes Institute 

The increasing global prevalence of and our aging population has given rise to an epidemic of heart failure. Up to one-third of patients in clinical heart failure trials are diabetic, and diabetes is an independent predictor of poor outcome. Despite the higher rate of heart failure in these patients, no specific treatment for heart failure exists for T2D patients. We and others have implicated elevated oxidative stress and cardiac generation of the ROS superoxide as likely contributors to this ‘diabetic cardiomyopathy’. More recently, we have identified novel mechanisms for limiting diabetes-associated cardiomyopathy, many of which specifically target the myocardium. Ultimately therapies based on these could pave the way for the development of much-needed, novel therapies that are specific for diabetic heart failure.

CiiiD Tuesday seminar: Dr Jamie Gearing, 30 May

This Tuesday seminar, 30 May, will feature Dr Jamie Gearing, a bioinformatician in the Regulation of Interferon and Innate Signalling lab at CiiiD.

Jamie will present on a variety of projects he is working on with the bioinformatics group.

1-2pm, Tuesday 30 May
Seminar Room 1, Level 2, TRF
Chair: Ms Zoe Marks

Seminars for the Centre for Inflammatory Diseases are held from 12-1pm in the same room. The CID seminar schedule can be found here:  Next week's CID speaker is Rebecca Ritchie from the Baker Institute.  If you would like to meet with Rebecca while she is visiting the Hudson Institute, please contact Dr  More information:

PhD Progress Review Milestone, SJ Shen, 1 June

All staff and students are invited to SJ Shen's milestone review.  Thursday 1 June, 2.30-4.30pm, Medicine Seminar Room, Block E, Level 5, MMC.

 Presentation Title: Investigating the role of dietary fibre in the modulation of immune function 
and leukocyte recruitment during colitis

 Synopsis: The interaction between fibre, iNKT cells, neutrophil recruitment and murine colitis is poorly understood. My project aims to 1) examine the role of iNKT cells on neutrophil recruit in DSS-induced colitis; 2) assess the role of fibre and acetate on healthy and diseases mice
Supervisors:  Dr Connie Wong and Prof. Michael Hickey 

 Panel Chair: Dr. Ashley Mansell

 Independent assessors: Dr. Adam Uldrich and Prof. William Sievert

Monash Haematology Journal Club, Wednesday 31 May 2017

7.30am Breakfast & 7.45am Presentation
Monash Medical Centre, Level 2 - Lecture Theatre 3

The Madness of King George

Presenter: Dr Prudence Smith

Grand Rounds presentation “Victorian Assisted Dying Law 2017. How should Our Politicians Vote?", 31 May

Professor Eva Segelov
Presenters: Professor Eva Segelov, Professor David Kissane
Topic:  “Victorian Assisted Dying Law 2017.  How should Our Politicians Vote?"
Date: Wednesday 31 May 2017
Time: 12.30pm to 2.00pm

Venue: Main Lecture Theatre, Monash Medical Centre, Clayton.

Monash Graduate Excellence Scholarships (MGES)

Monash University is proud to introduce the Monash Graduate Excellence Scholarships (MGES) , to support the recruitment of talented and high quality domestic students.

The MGES will provide a full-time living allowance of $10,000 per annum, and is awarded in addition to the Research Training Program (RTP) Stipend (formerly Australian Postgraduate Award).

Awardees must be:
  • an Australian or New Zealand citizen or Australian permanent resident; and
  • commencing a new graduate research degree at Monash University.

Applicants who are international, currently enrolled or have an offer of admission and/or scholarship are not eligible.

Up to 60 MGES are available in the current graduate research scholarship round which closes Wednesday 31 May 2017.  Applicants will automatically be considered for scholarships they are eligible for.

Further information including application details can be found online.

LabArchives 101 - Setting up and Q&A Sessions

The school will be running a 101 LabArchives session on Wednesday 14 June at 10 am, in Hudson Level 3 Boardrooms a&b.  This session is open to academics, research assistants and graduate students.
The training will be provided in two parts:
  • Session 1 (10.00 - 10.45 am)  Setting up your LabArchives for both Windows and Mac users
  • Session 2 (10.45 - 11.30 am)  Q&A session for anyone who is currently using LabArchives and has questions

For bookings please register:

Please bring your laptops to the first session to enable appropriate software installation.

PhD scholarship opportunity in prevention of diabetes and chronic diseases

PhD scholarship opportunity in prevention of diabetes and chronic diseases at the Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University

We are seeking talented medical candidates who wish to apply for a full-time scholarship to pursue a PhD. You should ideally have a background in diabetes or general medicine and an interest in the prevention of chronic diseases including diabetes and cardiovascular diseases.

About this PhD opportunity

The candidate will have an opportunity to learn how to plan and run a clinic trial, learn how to perform clinical research procedures such as glucose clamps, muscle and adipose tissue biopsies, measure central blood pressure, arterial stiffness and endothelial function, perform a systematic review, epidemiological modeling and health economic analyses. Within this research program, there is ample opportunity for the candidate to conduct independent research under the supervision of an expert research team.

About Monash Centre for Health Research and Implementation (MCHRI)
MCHRI sits within the School of Public Health and Preventive Medicine, Monash University and is a collaborative partnership with Monash Health. With over 50 staff and students we are a dynamic and growing multidisciplinary team of clinicians and researchers. 
MCHRI and its program leaders have internationally recognised reputations as research leaders for our strong links between cutting-edge public health and clinical research, evidence based medicine, implementation and translation.
We are a research active Centre with major project funding from the National Health & Medical Research Council.  We host NHMRC fellows and our team has published more than 100 articles in the last three years in many top peer reviewed journals.
MCHRI has an active and engaging clinical, health services and public health research training program that seeks to attract, train, mentor and build careers of those wishing to improve clinical health outcomes. 
At MCHRI it is our policy that all students are supervised by a team of senior experienced researchers  supported in a collegial environment with at least 10 PhD students working closely together. We anticipate that all students will successfully complete studies within three contact years. All students complete PhD studies by publication so they have a track record when they finish their research.  Importantly, we guarantee timely access to supervisors and rapid responses in return of submitted manuscripts.

About the PhD supervisors
Associate Professor Barbora de Courten, MD PhD FRACP MPH

Professor Helena Teede, MBBS PhD FRACP

Prof Danny Liew, MBBS PhD FRACP

Qualifications and financial Support
Candidate Requirements
·         A first class or 2A honours degree, MD, MBBS or equivalent;
·         Australian or New Zealand citizenship or permanent residency;
·         A candidate whose first language is not English should have a minimum IELTS score of 7, with no band below 6.5
Students with H1 equivalent are encouraged to apply for scholarship. An initial, one year scholarship (equivalent to Australian Postgraduate Association stipend) for 2017 is guaranteed, with opportunities to apply for further scholarships in subsequent years.  Preparation of scholarship applications will be supported and successful applicants will be eligible to apply for additional local top-up scholarship funds.
Commensurate with NHMRC PhD stipend (tax exempt), plus support for attendance at approved courses.
How to apply
Email your CV, a cover letter with a statement of intent and how this PhD scholarship would enhance your professional career, and a copy of your academic transcript to
Closing date: 5.00pm, by 31st August 2016.

AV in TRF Seminar Rooms

An external AV consultant has recently reviewed the resources in the TRF seminar rooms. The original 'gooseneck' microphones attached to the lecterns were found to be unsuitable for use and have been removed. Within each lectern cupboard, there is now a hand-held microphone and also a lapel microphone for seminar speakers to use. These two options will provide a better quality of sound. e-Solutions staff will re-charge the batteries on the hand-held microphones each week.
Please also note that there are power boards in each lectern, so that users of the room will no longer need to access the floor boxes for power.
There is a headphone jack within the connector loom in each of the seminar rooms; users can plug this into their laptop if they have presentations requiring sound.

OHS training courses - June / July 2017

Occupational Health & Safety Training Opportunities

Biosafety Level 1 - 5 July
Biosafety Level 2 - 5 July
CPR Refresher - 6 June, 14 July
Emergency Warden Training - 1 June, 14 June, 29 June, 12 July, 18 July
Essential OHS (OHS for Managers & Supervisors) - 14 June, 11 July
Fire Safety & Extinguisher Training - 18 July
First Aid Level 2 - 19 & 20 July, 27 & 28 July
First Aid Level 2 (Mixed Mode) - 10 July
First Aid Management of Anaphylaxis - 3 July
Hazardous Substances & Dangerous Goods Awareness - 15 June
Mental Health First Aid - 12 & 19 July
Radiation Safety Officer refresher - 7 July
Radiation Safety Officer training - 6 & 7 July
Risk Management & Risk Management Specialised - 28 June, 25 July
Workplace Safety Inspections - 28 July

Staff Development would like to advise that 2017 (June - July) workshop dates are available on the website.

We are here to support your work and welcome your feedback (

Participants needed to take part in a diabetes clinical trial

ü  A pre-diabetic OR have type 2 diabetes (diet-controlled or taking Metformin only)
ü  Aged between 18 and 70 years
ü  Someone with no significant weight change in the last 6 months or have no intention to lose weight in the next 3 months
ü  Not taking other regular medications
ü  Someone with no significant diseases that require treatment
ü  A non-smoker, non-drug user, non-high alcohol intake
ü  Not lactating, pregnant or planning to be in next 4-6 months
ü  Living in Melbourne

ü  $100 visa card or gift card of your choice as a token of appreciation
ü  Free diabetes and cardiovascular risk assessment
ü  Free body fat and muscle assessment (around $200 value)
ü  Free Fibroscan to assess condition of your liver
ü  Free routine blood tests
ü  Free cognitive tests

This study involves up to 5 visits over a period of approximately 14 weeks and takes place at Monash Medical Centre in Clayton. Medical certificates can be provided when needed.
For further information, or to take part, please contact Josphin Johnson @ 0385722629 or Email:
(This study has approval from the Monash Health Human Research Ethics Committee–Project Number 16061A).

Epstein-Barr virus encephalitis in solid organ transplantation

Tony Korman et al. published in New Microbiology.

Read article here.

Two weeks of repetitive gut-challenge reduces exercise associated gastrointestinal symptoms and malabsorption

Ricardo Costa et al. published in the Scandinavian Journal of Medicine and Science in Sports.

Read article here.

Retrospective Cohort Study Examining Reduced Intensity and Duration of Anticoagulant and Antiplatelet Therapy Following Left Atrial Appendage Occlusion with the WATCHMAN Device

M Tung et al. published in Heart, Lung & Circulation.

Read article here.

Neuroimaging and its Relevance to Understanding Pathways Linking Diabetes and Cognitive Dysfunction

Thanh Phan et al. published in the Journal of Alzheimer's disease.

Read article here.

Williams-Beuren Syndrome and Congenital Lobar Emphysema: Uncommon Association with Common Pathology?

Atul Malhotra et al. published in Case Reports in Pediatrics.

Read article here.

Prevalence of psychological distress: How do Australia and Canada compare?

Joanne Enticott et al. published in the Australian & New Zealand Journal of Psychiatry.

Read article here.

The significance of post-translational removal of α-DG-N in early stage endometrial cancer development

Sophea Heng et al. published in Oncotarget.

Read article here.

Healthcare Simulation Education: Evidence, Theory and Practice

Arunaz Kumar et al. published in Healthcare Simulation Education: Evidence, Theory and Practice

Book details here