|Dr Sarah Zaman|
Dr Sarah Zaman is a cardiologist at Monash Heart and Monash Health.
Dr Zaman will be presenting on "Primary Prevention of Sudden Cardiac Death after Myocardial Infarction".
Background: Patients who have survived a myocardial infarction (MI) with resultant impaired cardiac function are at high risk of sudden cardiac death (SCD). The risk of SCD is 6 times higher in the first month post-MI then thereafter, with a substantial risk in patients with more preserved cardiac function. However, current guidelines exclude such patients form receiving a primary prevention implantable-cardioverter-defibrillator (ICD).
Aims: The PROTECT-ICD Trial aims to prevent SCD through use of an electrophysiology study (EPS) to identify high risk patients early-post MI who may benefit from an ICD.
Methods: This is an international, multi-centre, randomised controlled trial of 1,058 patients with a left ventricular ejection fraction (LVEF)≤40% post-MI. Patients are randomised 1:1 to either early (3-40 days after MI) ICD implantation guided by electrophysiological study, or to standard care (ICD implanted >3 months post-revascularisation for MI if LVEF≤30% or ≤35% with heart failure). The primary outcome is SCD or non-fatal arrhythmia at 2-years.
Research Plan: The trial commenced in 2014 with 15% of target participants already recruited from 18 active sites across the AsiaPacific. With a further 10-20 sites being initiated in 2017, complete patient recruitment and 2-year follow up is projected to finish in 2020.
Significance/Expected Outcomes: The PROTECT-ICD Trial is unique in being the only study to target the important issue of early prevention of SCD in post-MI patients through the use of an electrophysiology study. The trial has the potential to change national and international guidelines for primary prevention of SCD and selection for defibrillator therapy
We look forward to welcoming Dr Zaman for the Symposium!
Translational Research Symposium
- Date: Monday 31 July, 2017
- Time: 8:30 for 9:00am start - 7:00pm close
- RSVP here
If you are a graduate student or early career researcher, you may be interested in the Young Investigator poster competition. See here for more details and to RSVP.