1pm, July 3rd, Hudson Boardroom.
Title: Delineating the role of activin A targets in men's reproductive health
Synopsis: Reproductive health is an important
aspect of men’s overall wellbeing, however, 1 in 20 men exhibit subfertility,
which is associated with a higher risk of developing testicular cancer. A
tightly regulated balance between somatic and paracrine signals mediates the
appropriate timing of gonocyte maturation, of which members of the TGF-beta
superfamily are substantially involved. Thus, my project investigates the
hypothesis that a particular member of this superfamily, activin A, alters the
level of chemokines (CXCL12, CCL17) and metalloproteinases (MMP2, MMP9) to
mediate gonocyte cell fate choice, with aberrant production of these factors
potentially contributing to testicular germ cell tumour development
Supervisors: Prof. Kate Loveland, A/Prof. Mark
Hedger, Prof. Martin Bergmann
Panel Chair: Dr. Craig Harrison
Independent assessors: Dr. Patrick Western, Dr.
Peter Stanton
No comments:
Post a Comment