1pm, July 3rd, Hudson Boardroom.
Title: Delineating the role of activin A targets in men's reproductive health
Synopsis: Reproductive health is an important aspect of men’s overall wellbeing, however, 1 in 20 men exhibit subfertility, which is associated with a higher risk of developing testicular cancer. A tightly regulated balance between somatic and paracrine signals mediates the appropriate timing of gonocyte maturation, of which members of the TGF-beta superfamily are substantially involved. Thus, my project investigates the hypothesis that a particular member of this superfamily, activin A, alters the level of chemokines (CXCL12, CCL17) and metalloproteinases (MMP2, MMP9) to mediate gonocyte cell fate choice, with aberrant production of these factors potentially contributing to testicular germ cell tumour development
Supervisors: Prof. Kate Loveland, A/Prof. Mark Hedger, Prof. Martin Bergmann
Panel Chair: Dr. Craig Harrison
Independent assessors: Dr. Patrick Western, Dr. Peter Stanton