The FY15 Defense Appropriations Act provides $8
million (M) to the Department of Defense Military Burn Research Program (MBRP) to
support high-impact burn injuries research. Applications to the Fiscal
Year 2015 (FY15) Military Burn Research Program (MBRP) are being solicited by
the U.S. Army Medical Research Acquisition Activity (USAMRAA). The
executing agent for the anticipated Program Announcements/Funding Opportunities
is the Congressionally Directed Medical Research Programs (CDMRP).
The MBRP is providing the information in this
pre-announcement to allow investigators time to plan and develop
applications. FY15 MBRP Program Announcement and General Application
Instructions for the following award mechanism are anticipated to be posted on
the Grants.gov website in late June or early July 2015. Pre-application and application deadlines will be available when the
Program Announcements are released. This pre-announcement
should not be construed as an obligation by the government.
Topic Areas: The MBRP
encourages applications that specifically address the critical needs of the
burn research community in one of the FY15 Topic Areas. The MBRP will solicit
research applications for the following FY15 Topics Areas:
1. Fluid
Resuscitation Studies (Human)
a)
Through multicenter prospective observational studies (retrospective
or prospective), demonstrate the impact of various fluid resuscitation rates
and techniques, as well as various adjunctive therapies (high-dose/low-dose
vitamin C, albumin timing, etc.) on clinically relevant outcomes during acute
burn resuscitation.
2. Organ
Failure Studies (Human)
a)
Through clinical studies, provide insight into the
epidemiology, prevention, early detection, and/or treatment of single or
multiple organ failure in the burn/trauma patient.
b)
Provide a systematic approach to define sepsis in
burns and the impact of sepsis-related outcomes through the identification and
establishment of best practice while evaluating longitudinal adherence to
established standards.
3.
Wound Healing (Animal/Human)
a)
Determine specific physiological factors that result
in delayed wound healing, such as shock, edema, immune system dysregulation,
etc.
b)
Evaluate or develop strategies (dressing, topicals,
biologics, etc.) that optimize healing of acute burn wounds.
c)
Identify diagnostic predictors (biomarkers, imaging
techniques, physical wound changes, etc.) that can be used to indicate failure
of wound healing.
4.
Prolonged Field Care and Delayed Evacuation
(Animal/Human)
a)
Determine the clinical impact of delayed definitive
therapy and/or resuscitation in a burn injury animal model.
b)
Through observational or retrospective studies,
describe the impact of delayed care at intermediary facilities, prolonged time
to initial treatment, and/or extended transport times on short- and long-term
patient outcomes (days on ventilator, development of organ complications,
compartment syndrome, limb loss, infection, etc.).
5.
Short- and Long-Term Functional Outcomes
a)
Through retrospective or prospective studies, identify
issues that effect, as well as strategies to improve, physical and/or mental
functional outcomes (both short- and long-term). Examples of items to
include are social reintegration, duration in intensive care units, range of
motion in the affected limb(s), number and types of procedures performed, the
use of coping strategies/interventions to mitigate post-traumatic stress
disorder, and other strategies that help improve patient outcomes after
discharge.
Burn
Injuries Research Award
Independent
investigators at all academic levels (or equivalent)
·
Supports innovative approaches to accelerate the
translation of advances in knowledge into new standards of care for the
treatment of the injured Warfighter who sustains burn injuries.
·
Must specifically address at least one of the FY15
Topic Areas
·
Research that is already supported by preliminary data
and has the potential to make significant advancements toward clinical
translation is required for Funding Level 1.
·
Advanced translational studies that have the potential
for near-term clinical investigation are required for Funding Level 2.
·
Clinical trials are allowed.
Pre
-
proposal is required; application submission is by invitation only
Funding
Level 1
·
The maximum period of performance is 3 years.
·
The maximum allowable funding for the entire period of
performance is $750,000 in total costs.
Funding
Level 2
·
The maximum period of performance is 4 years.
The maximum allowable funding for the entire period of
performance is $2 million in total costs.
A
pre-application is required and must be submitted through the electronic
Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the
pre-application deadline. All applications must conform to the final
Program Announcements and General Application Instructions that will be
available for electronic downloading from the Grants.gov website. The
application package containing the required forms for each award mechanism will
also be found on Grants.gov. A listing of all USAMRMC funding
opportunities can be obtained on the Grants.gov website by performing a basic
search using CFDA Number 12.420.
Applications
must be submitted through the federal government's single-entry portal, Grants.gov.
Submission deadlines are not available until the Program Announcements are
released. Requests for email notification of the Program Announcements
release may be sent to help@cdmrp.org. Email notifications of
funding opportunities are sent as a courtesy and should not be used as a sole
source of notification; applicants should monitor Grants.gov for official
postings of funding opportunities.
For more
information about the MBRP or other CDMRP-administered programs, please visit
the CDMRP website (http://cdmrp.army.mil).
Point of
Contact:
CDMRP Public Affairs
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