The Fiscal Year 2016 (FY16) Defense Appropriations Act
provides $3.2 million (M) to the Department of Defense Duchenne Muscular
Dystrophy Research Program (DMDRP) to
support innovative, high-impact Duchenne muscular dystrophy research. As
directed by the Office of the Assistant Secretary of Defense for Health
Affairs, the Defense Health Agency, Research, Development, and Acquisition (DHA
RDA) Directorate manages and executes the Defense Health Program (DHP)
Research, Development, Test, and Evaluation (RDT&E) appropriation.
The managing agent for the anticipated Program Announcements/Funding Opportunities
is the Congressionally Directed Medical Research Programs (CDMRP).
FY16 DMDRP Program Announcements and General
Application Instructions for the following award mechanisms are posted on the Grants.gov website.
The DMDRP FY16 Focus Areas are as follows:
All applications for the FY16 DMDRP funding
opportunities must address at least one of the
following focus areas:
· Cardiac
studies including identifying mechanisms of pathology and therapeutic
interventions
· Clinical
studies and novel interventions that could improve clinical care and quality of
life, in areas such as:
o Comorbidities
o Endocrinology
o Orthopedics
o Gastrointestinal issues
o Psychosocial issues
o Cognitive function
o Respiratory issues (including
sleep-focused studies)
· Assessment
of clinical trial tools and outcome measures, such as:
o Discovery
and qualification of pharmacodynamic, prognostic, and predictive biomarkers.
o Evaluating
surrogate markers
o Evaluating
potential composite scores for outcomes assessment
o Patient-centered
outcomes, e.g., quality of life, activities of daily living
· Extension
or expansion of existing preclinical translational data in support of a
specific therapeutic development path (including independent replication and
comparative studies)
Investigator-Initiated Research Award – Preproposal due 19 July 2016
Principal
Investigator: Must be an independent investigator at or above
the level of Assistant Professor (or equivalent).
Optional Nested Resident or Medical Student Trainee:
Resident trainee must be enrolled in an accredited residency program.
Medical student trainee must be enrolled in a nationally accredited (or
equivalent) medical school. Trainees must be able to devote a minimum of
40% level of effort.
Supports translational research that will have an
impact on improving the function, quality of life, and/or extending the
lifespan for all individuals with Duchenne.
Clinical trials are allowed.
Preliminary data
required.
Maximum funding of $600,000 in direct
costs (plus indirect costs).
Period of performance should not exceed 3 years.
Nested traineeship:
Additional maximum of $50,000 for residents or $30,000 for medical students in
direct costs (plus indirect costs) over a one-year period of performance.
Career Development Award – Preproposal due 19
July 2016
Principal
Investigator: PIs must be research (PhD) - or physician
(MD)-scientists at an early stage of their independent research careers within
5 years after completion of his/her terminal degree (excluding time spent in
residency or on family medical leave), and exhibit a strong desire to pursue a
career in Duchenne research.
Mentor: The mentor
must hold a position at or above the level of an Associate Professor (or
equivalent).
Supports early-career investigators to conduct impactful
research under the mentorship of an experienced muscular dystrophy researcher.
Clinical trials are not allowed.
Preliminary data
required.
Maximum
funding of $275,000 in direct costs (plus indirect costs).
Period of performance
should not exceed 2 years.
A pre-application is required and must be submitted
through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to
the pre-application deadline. All applications must conform to the final
Program Announcements and General Application Instructions that are available
for electronic downloading from the Grants.gov
website. The application package containing the required forms for each
award mechanism will also be found on Grants.gov. A listing of all CDMRP funding
opportunities can be obtained on the Grants.gov
website by performing a basic search using CFDA Number 12.420.
Applications must be
submitted through the federal government’s single-entry portal, Grants.gov. For email
notification when Program Announcements are released, go to the CDMRP website (http://cdmrp.army.mil) and
select Subscribe to Funding Opportunities & Program Communications.
For more information about the DMDRP or other CDMRP-administered programs,
please visit the CDMRP
website (http://cdmrp.army.mil).
For questions about the
research programs, please contact the MRO Research Grants & Contracts Team
(adm-researchgrants.contracts@monash.edu).
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