All staff and students are invited to Majid Alhomrani's pre-submission seminar.
Wednesday 13 December, 1pm, Medicine seminar room, level 5, Block E, MMC
Presentation title " Human amnion epithelial cells, a
potential therapy for liver injury"
Synopsis: Chronic liver diseases are characterised by progressive hepatocyte
injury, which results in wound healing responses, inflammation and the
accumulation of extracellular matrix (ECM). The size of the population
affected with chronic liver disease has been disproportionally increased, and
the costs of this increase are enormous. There are many causes of
chronic liver disease including viral hepatitis, alcoholic liver disease and
non-alcoholic fatty liver disease. Currently,the only effective treatment for
end-stage liver disease is orthotopic liver transplantation (OLT). Human
Amniotic Epithelial Cells (hAECs) are isolated from the amnion of the placenta
in sufficient numbers for clinical use, and bear many characteristics of
traditional stem cells including pluripotent ability, low immunogenicity,
anti-inflammatory and anti-fibrotic effects. Extracellular vesicles (EVs) are
complex membrane enclosed nanoparticles that carry a cargo of select proteins,
RNAs, and lipids. I will explore the therapeutic efficacy of hAECs and hAEC-EV
in reducing hepatic fibrosis
Supervisors: Prof William Sievert and Dr. Rebecca Lim
All staff and students are invited to Majid Alhomrani's pre-submission seminar.
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