This workshop will look briefly at recently developed range of fluorescence based protocols and imaging techniques that are bringing a new importance to the histopathological analysis of the tissue and tumor microenvironment, giving the researcher better insight into the complexities of tumor immune responses and potentially pathologists a more accurate insight for better clinical outcomes
This new development combines: the sequential multi-biomarker labeling of up to 8 antigens using antibodies all of the same species in a single tissue section; multispectral imaging (MSI) to remove the typically problematic formalin fixed paraffin embedded ( FFPE) tissue autofluorescence and correct cross-talk between fluorescent channels; and an automated analysis that can quantitate the per-cell biomarker expression to determine cellular phenotype and their distribution within in the tumor microenvironment.
When these powerful methods of fluorescence based imaging are applied to cancer immunology, we can open up contextual windows, synergizing with highly multiplexed, yet contextually naïve, flow cytology and genomic methods and far more informative to the currently used IHC methods commonly used in tumor and tissue research and diagnosis.
To register for the seminar please contact: kirstin.elgass@hudson.org.au by COB 24 October.
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