Summary:
Tuberculosis,
caused by Mycobacterium tuberculosis, is a leading infectious killer worldwide,
with an estimated 10 million people affected and 1.5 million dying per annum.
Treatment encompasses a prolonged course of numerous antimicrobials, with a
growing trend of multi-resistance and limited repertoire of available
therapies. In combating this challenge, an understanding of the host-organism
interactions was sought, in particular, characterisation of various adaptor
proteins involved in TNF signaling, a cytokine that has been shown to be
essential in maintaining control of the organism. The presented work explores
Mtb’s effect on various cell death proteins using an aerosolized model of
murine tuberculosis, simultaneously exploring the effect of pro-apoptotic
therapies on bacterial burdens in mice and shows that induction of macrophage
death may have a role as novel immunomodulatory therapies in the fight against
Mtb.
Samar graduated from Monash University and completed
her basic physician and Infectious diseases training at Monash Health, before
moving to Sydney where she competed training in clinical immunology and
immunopathology. She currently works at Monash in adult ID and within the
Infection and Immunity unit at Monash Children's Hospital. She recently
completed a PhD through the University of Melbourne, at the Walter and Eliza
Hall Institute, where she set up a murine tuberculosis model which formed the
basis of her work on cell death in tuberculosis.
Lunch will be served from 11.45am outside the seminar room.
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