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Monday 4 September 2017

CID seminar: "Die And Let Live? Proapoptotic therapies in tuberculosis", 5 September

Tuesday 5 September, 1-2pm, Seminar room 1, Level 2, TRF


Summary: 
Tuberculosis, caused by Mycobacterium tuberculosis, is a leading infectious killer worldwide, with an estimated 10 million people affected and 1.5 million dying per annum. Treatment encompasses a prolonged course of numerous antimicrobials, with a growing trend of multi-resistance and limited repertoire of available therapies. In combating this challenge, an understanding of the host-organism interactions was sought, in particular, characterisation of various adaptor proteins involved in TNF signaling, a cytokine that has been shown to be essential in maintaining control of the organism. The presented work explores Mtb’s effect on various cell death proteins using an aerosolized model of murine tuberculosis, simultaneously exploring the effect of pro-apoptotic therapies on bacterial burdens in mice and shows that induction of macrophage death may have a role as novel immunomodulatory therapies in the fight against Mtb.


Samar graduated from Monash University and completed her basic physician and Infectious diseases training at Monash Health, before moving to Sydney where she competed training in clinical immunology and immunopathology. She currently works at Monash in adult ID and within the Infection and Immunity unit at Monash Children's Hospital. She recently completed a PhD through the University of Melbourne, at the Walter and Eliza Hall Institute, where she set up a murine tuberculosis model which formed the basis of her work on cell death in tuberculosis. 

Lunch will be served from 11.45am outside the seminar room.

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