Monday, 27 February 2017

CID Weekly Seminar: "Toll-like receptors and their function in mycobacterial infections -a longitudinal translational study examining infected patients" Tuesday 28 February

Tuesday 28 February, 12:00 - 1:00pm, Seminar Room 1, Level 2, TRF Building

Dr Sabine de Silva
Infectious Diseases Physician, Department of Infectious Diseases, Monash Health
Postgraduate Student, Centre for Inflammatory Diseases

Thesis Pre-submission seminar 

Tuberculosis infections affect a third of the world's population.  Many challenges are faced in the diagnosis, treatment and vaccination against TB.  Results from a  pilot study at Monash Health conducted to examine affects of treatment on innate immune markers will be presented, including toll-like receptor (TLRs) expression and their functional effects through anti-tuberculous therapy.  TLR 2, 4 & 7 expression varies significantly on different cell types through treatment, as do their effects on cytokine production.  I will discuss the changes which occur in TNF, IL6 and MCP1 levels following specific TLR-ligand stimulation in these patients.  Comparison will be made between those with active TB infection and those with latent TB infection (LTBI).   The correlation with low vitamin D levels and TLR expression will also be discussed.  Further research into the changes found between the two cohorts may potentially enable these changes to be incorporated into a platform to differentiate between the two groups- a crucial and currently unavailable entity.
Dr Sabine de Silva graduated from Monash University in 2000, having completed MBBS (H) and BMedSci (H). Completed Infectious Diseases training at Monash, Austin and Barwon Health and currently an Infectious Diseases Physician at Monash Health.  Interests include clinical research, particularly in TB. 

A light lunch is served prior to the seminar at 11:45am in the seminar room foyer, level 2, TRF Building.

Further information, including the link to add the seminar series to your google calendar, is available from CID Weekly Seminar Series website []

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