Tuesday 28 February, 12:00 - 1:00pm, Seminar
Room 1, Level 2, TRF Building
Dr Sabine de
Silva
Infectious
Diseases Physician, Department of Infectious Diseases, Monash Health
Postgraduate
Student, Centre for Inflammatory Diseases
Thesis
Pre-submission seminar
Tuberculosis infections affect a third of the
world's population. Many challenges are faced in the diagnosis, treatment
and vaccination against TB. Results from a pilot study at Monash
Health conducted to examine affects of treatment on innate immune markers will
be presented, including toll-like receptor (TLRs) expression and their
functional effects through anti-tuberculous therapy. TLR 2, 4 & 7
expression varies significantly on different cell types through treatment, as
do their effects on cytokine production. I will discuss the changes which
occur in TNF, IL6 and MCP1 levels following specific TLR-ligand stimulation in
these patients. Comparison will be made between those with active TB
infection and those with latent TB infection (LTBI). The correlation
with low vitamin D levels and TLR expression will also be discussed.
Further research into the changes found between the two cohorts may
potentially enable these changes to be incorporated into a platform to
differentiate between the two groups- a crucial and currently unavailable
entity.
Dr Sabine de Silva graduated from Monash
University in 2000, having completed MBBS (H) and BMedSci (H). Completed
Infectious Diseases training at Monash, Austin and Barwon Health and currently
an Infectious Diseases Physician at Monash Health. Interests include
clinical research, particularly in TB.
A light lunch is served prior to the seminar at 11:45am in the
seminar room foyer, level 2, TRF Building.
Further information, including the link to add the seminar
series to your google calendar, is available from CID Weekly Seminar Series
website [http://www.med.monash.edu.au/scs/medicine/cid/seminar-series.html]
Tuesday 28 February, 12:00 - 1:00pm, Seminar
Room 1, Level 2, TRF Building
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