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Tuesday, 23 January 2018

Development and validation of a written credentialing examination for overseas-educated dietitians

Claire Palermo et al. published in Nutrition and Dietetics.

Read article here.

Five-Year Recurrence Rate and the Predictors Following Stroke in the Mashhad Stroke Incidence Study: A Population-Based Cohort Study of Stroke in the Middle East

Amanda Thrift et al. published in Neuroepidemiology.

Read article here.

Elderly patients with suspected chronic digoxin toxicity: A comparison of clinical characteristics of patients receiving and not receiving digoxin-Fab

Andis Graudins et al. published in Emergency Medicine Australasia.

Read article here.

Don't just do something, stand there! The value and art of deliberate clinical inertia

Diana Egerton-Warburton et al. published in Emergency Medicine Australasia.

Read article here.

The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis

Jonathan Dick et al. published in PLoS One.

Read article here.

The utility of DNA extracted from saliva for genome-wide molecular research platforms

Melissa Southey et al. published in BMC Research Notes.

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Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

Melissa Southey et al. published in the International Journal of Epidemiology.

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Konjac flour noodles associated with gastric outlet obstruction

Gabriel Blecher et al. published in Emergency Medicine Australasia.

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Does obesity reduce risk for osteoporosis and fractures in older adults?

David Scott et al. published in Internal Medicine Journal.

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Evaluation of AJCC and an Alternative Tumor Classification System for Primary Vulvar Squamous Cell Carcinoma

Beverley Vollenhoven et al. published in the Journal of the National Comprehensive Cancer Network.

Read article here.

Immune-mediated kidney disease in 2017: Progress in mechanisms and therapy for immunological kidney disease

Stephen Holdsworth, Richard Kitching published in Nature Reviews Nephrology.

Read article here.

Risk Predictors and Causes of Technique Failure Within the First Year of Peritoneal Dialysis: An Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) Study

Kevan Polkinghorne et al. published in the American Journal of Kidney Diseases.

Read article here.

The utility of personal activity trackers (Fitbit Charge 2) on exercise capacity in patients post acute coronary syndrome [UP-STEP ACS Trial]: a randomised controlled trial protocol

Arthur Nasis et al. published in BMC Cardiovascular Disorders.

Read article here.

Acceptability of opt-out consent in a hospital patient population

Suong Le et al. published in Internal Medicine Journal.

Read article here.

The impact of melatonin on the sleep patterns of women undergoing IVF: a double blind RCT

Shavi Fernando et al. published in Human Reproduction Open.

Read article here.

Amnion Epithelial Cell-Derived Exosomes Restrict Lung Injury and Enhance Endogenous Lung Repair

Rebecca Lim et al. published in Stem Cells Translational Medicine.

Read article here.

Maternal gestational weight gain during pregnancy: prioritising the conversation

Ruth Walker et al. published in the Australian Journal of Primary Health.

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Cardiovascular autonomic dysfunction in sudden infant death syndrome

Rosemary Horne published in Clinical Autonomic Research.

Read article here.

Tuesday, 16 January 2018

Alcohol-related harm taking a toll in hospital emergency departments—more than half a million admissions each year

Associate Professor Egerton-Warburton
A world-first research study investigating the burden of alcohol harm has revealed that almost one in ten presentations to hospital emergency departments is alcohol-related.

Led by Monash University researcher and Monash Health Director of Emergency Medicine Research Associate Professor Diana Egerton-Warburton, the first large-scale international, multisite, prospective study into the total burden of alcohol harm presenting to emergency departments (EDs) shows the burden is higher than previously thought.

Alcohol is a major cause of death and disability internationally, resulting in an estimated 5.9% of all deaths.

Associate Professor Egerton-Warburton said alcohol-related harm accounts for 3.3 million deaths annually and is also linked to over 200 diseases.

“EDs are at the frontline of treating the health and social consequences of alcohol-related harm,” Associate Professor Egerton-Warburton said.

“Our study is the first in the world to include the total burden of alcohol-related harm, including physical injuries, intoxication, medical conditions and indirect injuries caused by a third party affected by alcohol.”

“It’s shocking that more than half a million people every year present to our EDs in Australia as a direct result of alcohol—bearing in mind these are preventable admissions.”

Eight hospital EDs across Australia and New Zealand—representing metropolitan, rural and regional populations—screened nearly 8500 patients over a seven-day period in December 2014.  Of these, 801 presentations (or 9.5%), were identified as being alcohol positive according to the study criteria.

“These findings verify previous data that demonstrated high levels of alcohol-related presentations overnight during weekends, but also demonstrate that patients with alcohol-related conditions are presenting to EDs at all times throughout the week,” Associate Professor Egerton-Warburton said.

Patients with alcohol-related harm are more likely to be younger, male, be triaged for immediate care, and arrive via ambulance or police.

Associate Professor Egerton-Warburton said these types of patients are resource intensive, and may be violent and aggressive to staff and other patients. 

“They have been found to disrupt the function of the ED and negatively impact on the care of other patients,” she said.

“Our previously published clinical survey found that nine out of 10 emergency clinicians had experienced violence from alcohol-affected patients over the last year.”

“Alcohol consumption has a significant impact on the healthcare system as reflected in the prevalence of alcohol-related presentations occurring daily in our EDs, and as alcohol-related harm is an inherently preventable condition, this represents a strong case for preventative public health interventions,” Associate Professor Egerton-Warburton said.

“Restricting the availability of alcohol through early closing of licenced venues has demonstrated a significant reduction in ED alcohol-related presentations internationally.”


Associate Professor Egerton-Warburton said this research adds to the compelling argument for widespread introduction of restricted trading hours to reduce harms and healthcare costs.

Setting the priorities for paediatric emergency medicine research

Associate Professor Simon Craig
A large collaborative study of paediatric emergency researchers across Australia and New Zealand, including researchers at Monash University, has identified asthma management, emergency intubation, imaging of suspected cervical spine injuries and management of sepsis as priority areas for future multicentre research.

Published in the Emergency Medicine Journal and conducted through the Paediatric Research in Emergency Departments International Collaborative (PREDICT) network (www.predict.org.au), the research collaboration includes all hospitals with major paediatric emergency departments across Australia and New Zealand.

Monash University researcher and Monash Health paediatric emergency medicine physician Associate Professor Simon Craig was co-author on the study that surveyed practising senior paediatric emergency physicians to identify priorities for future research.

“We identified a number of key areas which clinicians believe should be a focus for acute paediatric research in the next few years: high flow oxygenation in intubation, fluid volume resuscitation and vasopressor use in sepsis, imaging in cervical spine injury, and intravenous therapy for asthma,” Associate Professor Craig said.

“These topics are relevant to clinicians practicing anywhere in the world, and have been independently identified by similar studies in the UK, Ireland and North America. Given the nature of paediatric emergency medicine, we are likely to need global collaboration to answer these research questions.”

Associate Professor Craig said there have been concerns raised regarding research waste, either through poor design, lack of publication, or incomplete reporting.

“Crucially, it has been estimated that around half of all research studies do not take into account lessons and results from previous related research,” Associate Professor Craig said.

“An understanding of the research priorities for practicing clinicians allows us to ensure that these topics are systematically examined to identify gaps in evidence, and/or gaps in knowledge translation, prior to the design of future trials.”

“Interestingly, we also identified a number of areas where practicing clinicians identified research questions which had already been answered by existing studies – either by clinical trials or systematic reviews. This highlights the importance of translating research knowledge into clinical practice which remains a challenge for acute paediatric care.”