26 March, 1.30pm, Level 2 meeting room, Hudson Institute
Presentation title: The role of NLRC5 in Helicobacter-induced inflammation and lymphoid tissue formation
Synopsis: Helicobacter
pylori is an extracellular mucosal pathogen that colonises
up to half of the world’s population and establishes chronic infection, which
can ultimately lead to gastric cancer. The newly discovered NOD-like
receptor, NLRC5 has been shown to regulate host-defence mechanisms against
viral and bacterial infection. My PhD aims to investigate the mechanisms of
NLRC5-mediated regulation of pro-inflammatory responses induced by macrophages
during Helicobacter gastritis and gastric MALT lymphoma.
Identifying a new role for NLRC5 in the context of Helicobacter infection,
may provide insight into the progression and development of H. pylori-related
diseases which pose as disease burdens in the community.
Supervisors: A/Prof
Richard Ferrero and Dr. Jonathan Ferrand
Panel Chair: Dr.
Connie Wong
Independent assessors: Dr.
Michelle Tate (Hudson) and Prof. Stephen Turner (Monash University)
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