PhD confirmation Fabrizzio Horta, Effects of oocyte aging on the repair of sperm DNA damage and on embryo development, 16 October

All staff and students are invited to Fabrizzio Horta's PhD confirmation.

16th October between 2:30pm-4:30pm, Room SR6 Monash Medical Centre.

Project title: Effects of oocyte aging on the repair of sperm DNA damage and on embryo development

Synopsis: The DNA repair by the oocyte is believed to rely on the maternal repair pathway mRNAs that are stored in the oocyte before ovulation. However, previous studies suggest that with increasing maternal and/or oocyte age, these stored mRNAs decrease resulting in a decrease in the efficiency of DNA repair. On the other hand, sperm DNA damage has shown a decreased effect on reproductive outcomes using oocytes from young women, which it could be explained by the high DNA repair capacity. However, further studies should be carried out.

Supervisors:  Peter Temple-Smith, Sally Catt and Beverley Vollenhoven