12-1pm, 12 September, Seminar room 1, Level 2, TRF
Synopsis: Infection is a common complication after stroke and contributes to worsening of stroke patient outcome. While antibiotics are the go-to treatment for post-stroke infections, antibiotics have been found to be ineffective in recent clinical trials. Major clinical trials that explored preventive antibiotic therapy do not recommend the use of prophylactic antibiotics as it does not improve stroke patient outcome. Also, with the rise of antibiotic resistance, there is a clear need for better targeted therapeutics to reduce infection, which can be revealed by exploring the mechanisms of post-stroke infection. Evidence over the past two decades allude to the phenomenon of stroke-induced immunosuppression. The talk will describe the changes to the hosts' immune system following stroke that leave it susceptible to infection and discusses some recently acquired experimental data on the impact of stroke severity on immunosuppression and infection.
Supervisors: Dr Connie Wong, Dr Shu Wen Wen, Prof. Christopher Sobey
After completing his honours at the SCS in 2015, Ray
began his PhD in mid-2016 under the supervision of Dr. Connie Wong, Dr. Shu Wen
and Prof. Chris Sobey. Over the past few years of his research, Ray has
developed an interest in the ability of the brain and central nervous system in
influencing immunity. Ray will be presenting at the CID seminar as part of his
first PhD milestone.
Lunch will be served from 11.45am.
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