Prof Steven Gerondakis
Professorial Fellow, Department of Biochemistry and Molecular Biology
Monash University
We have previously reported that the
NF-kB pathway controls Treg development in the thymus by promoting thymocyte
commitment to this lineage and controlling the subsequent induction of Foxp3 in
Treg precursors. However, the mechanisms by which NF-kB controls these steps
are remain unclear. The post-developmental roles of NF-kB in Tregs also remain
unclear. Here I will describe recently published data outlining the role of
RelA in peripheral Treg function and revisit how we think c-Rel is controlling
Treg development.
Prof Steve Gerondakis did his PhD at
the WEHI characterising c-myc translocations in murine plasmacytomas
(1980-18084), then undertook a post-doctoral stint in the lab of JM Bishop at
UCSF (1984-1987) studying avian oncogenic viral induction of leukaemia. In
1988, he returned to WEHI to establish an independent lab during which time he
developed his interest in NF-kB signalling. From 2008-2011, he held a
professorial position at the Burnet Institute; from 2012-2014, he was a
Professorial fellow at Monash Centre for Blood Diseases and currently is a
Professorial fellow in the Monash Department of Biochemistry and Molecular
Biology where he continues his work on the diverse roles of theNF-kB pathway in
immune development and inflammation.
Please contact Andrea
Johannessen (andrea.johannessen@monash.edu)
to schedule a meeting with Steve after the seminar.
A light lunch is served prior to the seminar at
11:45am in the seminar room foyer, level 2, TRF Building.Further information, including the link to add the seminar series to your google calendar, is available from CID Weekly Seminar Series website [http://www.med.monash.edu.au/scs/medicine/cid/seminar-series.html]
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